A publication in Human Reproduction highlights the ability to culture secondary follicles from cryopreserved macaque ovarian tissue. The authors Ting, Yeoman, Lawson, and Zelinski compared ovarian tissue after slow-freezing or vitrification and found that vitrification appeared to better maintain the morphology of stromal cells and secondary follicles, and the ability to form an antrum during 3D follicle culture.
In the News
New Publication Online: In vitro development of secondary follicles from cryopreserved rhesus macaque ovarian tissue after slow-rate freeze or vitrification
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Friday, May 4, 2012
New Oncofertility Publication: Embryonic Fibroblasts Enable the Culture of Primary Ovarian Follicles Within Alginate Hydrogels
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Friday, May 4, 2012
In a recent publication in Tissue Engineering, Oncofertility Consortium® researchers examined the use of mouse embryonic fibroblasts (MEFs) in conjunction with a 3D-hydrogel-supported culture of ovarian follicles. Authors, Tagler, Tu, Smith, Anderson, Tingen, Woodruff, and Shea, found that coculture with the MEFs resulted in the survival and growth of primary and secondary follicles during the 14 days of culture.
New Publication Online: Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice
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Friday, May 4, 2012
In a publication in Tissue Engineering, Oncofertility Consortium® researchers identified new methods that may be utilized to increase the success of ovarian transplantation after cryopreservation. When ovarian tissue is transplanted back into a woman who preserved her fertility, revascularization of the tissue takes some time, during which many ovarian follicles are lost due to lack of oxygen and glucose.
New Publication Online: Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles
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Friday, May 4, 2012
In a publication from Human Reproduction, Oncofertility Consortium® researchers investigate how common patient-specific variables, such as age, weight, and stage in the menstrual cycle, may affect the culture of ovarian follicles. Authors, Hirshfeld-Cytron, Duncan, Xu, Jozefik, Shea, and Woodruff examined how in vitro follicle growth was impacted in mouse models with similar variables.
Response Piece in Journal of Adolescent and Young Adult Oncology from Oncofertility Researcher, Gwendolyn Quinn
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Thursday, May 3, 2012
The field of adolescent and young adult oncology (AYAO) is developing and evolving, providing fertile ground for debate, discussion and the exchange of opinions. In the “Controversies” feature of the Journal of Adolescent and Young Adult Oncology, the editors pose a key AYAO question to people from various organizations, geographical locations and professions. In this issue, they asked respondents about the challenges they encounter conducting qualitative psychosocial research for AYA patients and survivors.
Oncofertility Consortium Members, Jessica Hornick, Francesca Duncan, Lonnie Shea and Teresa K. Woodruff, Publish New Study in the Journal of Human Reproduction
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Tuesday, May 1, 2012
In this new study, the authors used the characteristic architecture of the rhesus macaque ovary, which is similar to the human ovary in terms of morphology and physiology, to devise robust isolation and culture methods for primate primordial follicles. Primordial follicles are con- fined to the ovarian cortex, which is a rigid physical environment com- pared with the medulla where growing follicles are found.
New Publication by Oncofertility Consortium Researchers, Gwendolyn P. Quinn, Caprice Knapp, Devin Murphy, Kelly Sawczyn and Leonard Sender
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Tuesday, May 1, 2012
Survival takes precedence for adolescent patients with cancer and their families. Patients may not discuss their treatments’ potential to damage their reproductive capacity, which has significant psychological late effects in survivorship. This new study aims to identify whether a health-related quality of life (HRQoL) instrument intended to capture reproductive concerns is sensitive and appropriate for adolescent patients with cancer.
NEW STUDY: Are you 13-29yrs old, have a history of cancer, and love playing video games? Sign up!
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Thursday, April 5, 2012
Kate Timmerman, PhD, named by the American Association of Medical Colleges to the Women in Medicine and Science Steering Committee
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Friday, March 23, 2012
Recently on the OHSU Effect Talk Radio Show: Preserving Fertility During Cancer with Mary Zelinski, PhD
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Friday, March 23, 2012
Oncofertility Consortium® researchers David M. Lee, MD, and Mary B.
